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Salmonella-Delivered COBRA-HA1 Antigen Derived from H1N1 Hemagglutinin Sequences Elicits Broad-SpectrumProtection Against Influenza A Subtypes Article

Ram Prasad Aganja, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee

Engineering 2024, Volume 32, Issue 1,   Pages 42-57 doi: 10.1016/j.eng.2023.08.001

Abstract:

A universal vaccine is in high demand to address the uncertainties of antigenic drift and the reduced effectiveness of current influenza vaccines. In this study, a strategy called computationally optimized broadly reactive antigen (COBRA) was used to generate a consensus sequence of the hemagglutinin globular head portion (HA1) of influenza virus samples collected from 1918 to 2021 to trace evolutionary changes and incorporate them into the designed constructs. Constructs carrying different HA1 regions were delivered into eukaryotic cells by Salmonella-mediated bactofection using a Semliki Forest virus RdRp-dependent eukaryotic expression system, pJHL204. Recombinant protein expression was confirmed by Western blot and immunofluorescence assays. Mice immunized with the designed constructs produced a humoral response, with a significant increase in immunoglobulin G (IgG) levels, and a cell-mediated immune response, including a 1.5-fold increase in CD4+ and CD8+ T cells. Specifically, constructs #1 and #5 increased the production of interferon-γ (IFN-γ) producing CD4+ and CD8+ T cells, skewing the response toward the T helper type 1 cell (Th1) pathway. Additionally, interleukin-4 (IL-4)-producing T cells were upregulated 4-fold. Protective efficacy was demonstrated, with up to 4-fold higher production of neutralizing antibodies and a hemagglutination inhibition titer > 40 against the selected viral strains. The designed constructs conferred a broadly protective immune response, resulting in a notable reduction in viral titer and minimal inflammation in the lungs of mice challenged with the influenza A/PR8/34, A/Brisbane/59/2007, A/California/07/2009, KBPV VR-92, and NCCP 43021 strains. This discovery revolutionizes influenza vaccine design and delivery; Salmonella-mediated COBRA-HA1 is a highly effective in vivo antigen presentation strategy. This approach can effectively combat seasonal H1N1 influenza strains and potential pandemic outbreaks.

Keywords： COBRA     Influenza A     Salmonella     Vaccine     Broad spectral protection    

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Applying the spectral stochastic finite element method in multiple-random field RC structures

Abbas YAZDANI

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 4,   Pages 434-447 doi: 10.1007/s11709-022-0820-6

Abstract: This paper uses the spectral stochastic finite element method (SSFEM) for analyzing reinforced concrete

Keywords： uncertainty     spectral stochastic finite element method     correlation length     reliability assessment     reinforced    

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Fault feature extraction of planet gear in wind turbine gearbox based on spectral kurtosis and time wavelet

Yun KONG, Tianyang WANG, Zheng LI, Fulei CHU

Frontiers of Mechanical Engineering 2017, Volume 12, Issue 3,   Pages 406-419 doi: 10.1007/s11465-017-0419-0

Abstract: the fault feature of planet gear effectively, we propose a novel feature extraction method based on spectralFirstly, the spectral kurtosis (SK) and kurtogram of raw vibration signals are computed and exploited

Keywords： wind turbine     planet gear fault     feature extraction     spectral kurtosis     time wavelet energy spectrum    

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Low-Cost Federated Broad Learning for Privacy-Preserved Knowledge Sharing in the RIS-Aided Internet of

Xiaoming Yuan,Jiahui Chen,Ning Zhang,Qiang Ye,Changle Li,Chunsheng Zhu,Xuemin Sherman Shen,

Engineering doi: 10.1016/j.eng.2023.04.015

Abstract: privacy and improve data learning efficiency in knowledge sharing, we propose an asynchronous federated broadlearning (FBL) framework that integrates broad learning (BL) into federated learning (FL).In FBL, we design a broad fully connected model (BFCM) as a local model for training client data.

Keywords： Knowledge sharing     Internet of Vehicles     Federated learning     Broad learning     Reconfigurable intelligent surfaces    

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Implement and Innovate Environmental Protection Measures, Promote Green Protection of Cultural Relics

Fu-qing Liang,Yong-ping Sun

Frontiers of Engineering Management 2014, Volume 1, Issue 4,   Pages 330-335 doi: 10.15302/J-FEM-2014055

Abstract: The subject is implementing and innovating environmental protection measures, and promoting green protection

Keywords： environmental science     the Three Gorges cultural relics     innovate environmental protection measures     greenprotection    

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A Miniature Meta-Optical System for Reconfigurable Wide-Angle Imaging and Polarization-Spectral Detection

Fei Zhang,Minghao Liao,Mingbo Pu,Yinghui Guo,Lianwei Chen,Xiong Li,Qiong He,Tongtong Kang,Xiaoliang Ma,Yuan Ke,Xiangang Luo,

Engineering doi: 10.1016/j.eng.2023.07.008

Abstract: Wide-angle imaging and spectral detection play vital roles in tasks such as target tracking, object classificationproof-of-concept demonstration, the simultaneous implementation of wide-angle imaging and polarization-spectralThe proposed system supports the imaging (spectral) resolution of approximately 27.8 line-pairs per millimeter(lp·mm−1; ∼80 nm) for an imaging (spectral) mode from 8 to 14 μm.

Keywords： Metasurfaces     Reconfigurable     Imaging     Spectral    

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Nongray radiation from gas and soot mixtures in planar plates based on statistical narrow-band spectral

Huaqiang CHU, Qiang CHENG, Huaichun ZHOU, Fengshan LIU

Frontiers in Energy 2011, Volume 5, Issue 2,   Pages 149-158 doi: 10.1007/s11708-010-0124-8

Abstract: Based on the statistical narrow-band (SNB) spectral model with an exponential-tailed inverse intensity

Keywords： soot     combustion     SNB model     nongray radiation    

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Application of spectral technology in flame measurement

Jiaxun LIU, Xiaoshu CAI, Zenghao ZHU, Huinan YANG

Frontiers in Energy 2014, Volume 8, Issue 1,   Pages 138-143 doi: 10.1007/s11708-013-0283-5

Abstract: Spectral technology has become an important detection method due to its advantages such as non-intrusiveIn this paper, two applications of spectral technology in thermal detection were proposed.

Keywords： spectrum     emissivity measurement     component of fuel     near-infrared spectrometer    

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Spectral characteristics of plant communities from salt marshes: A case study from Chongming Dongtan,

ZHANG Liquan, GAO Zhanguo, Armitage Richard, Kent Martin

Frontiers of Environmental Science & Engineering 2008, Volume 2, Issue 2,   Pages 187-197 doi: 10.1007/s11783-008-0004-1

Abstract: The spectral reflectance of recently formed salt marshes at the mouth of the Yangtze River, which areSpectral data were processed concerning reflectance, and the averaged reflectance values for each samplewere re-analysed to correspond to a 12-waveband bandset of the Compact Airborne Spectral Imager.The spectral data were summarised using principal components analysis (PCA) and the relationships betweenthe vegetation composition, and the PCA axes of spectral data were examined.

Keywords： Spectral     multi-seasonal hyperspectral     invasive     JR     re-analysed    

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Spectral element modeling based structure piezoelectric impedance computation and damage identification

Zhigang GUO, Zhi SUN

Frontiers of Structural and Civil Engineering 2011, Volume 5, Issue 4,   Pages 458-464 doi: 10.1007/s11709-011-0133-7

Abstract: The numerical model is set up using the spectral element method, which is promised to be of high numerical

Keywords： PZT     piezoelectric impedance     optimization     spectral element     damage identification    

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Rapid and long-effective removal of broad-spectrum pollutants from aqueous system by ZVI/oxidants

Sana Ullah, Xuejun Guo, Xiaoyan Luo, Xiangyuan Zhang, Siwen Leng, Na Ma, Palwasha Faiz

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 5, doi: 10.1007/s11783-020-1268-3

Abstract: have been extensively applied to increase the reactivity of the ZVI surface toward the elimination of broad-spectrumSubsequently, the effect of three typical oxidants (H2O2, KMnO4, and NaClO) on broad-spectrum contaminants

Keywords： Zero-Valent Iron (ZVI)     Oxidants     Heavy Metals (HMs)     Metalloids     Nitrate     Phosphate    

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Technology of Measurement and Control by Welding Arc Spectral Information and Its Application

Li Junyue,Yang Yunqiang,Li Huan,Zhang Xiaonan,Yang Lijun

Strategic Study of CAE 2001, Volume 3, Issue 7,   Pages 21-29

Abstract:

Welding arc is full of spectral information.situation of the research on this field, expounded the principle of measurement and control by welding arc spectralinformation, described the application situation of welding arc spectral information, for example, theAt the same time, the authors have also introduced the application of arc spectral information in the

Keywords： spectral information     welding arc     plasma     diagnosis     automation    

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An anchor-based spectral clustering method None

Qin ZHANG, Guo-qiang ZHONG, Jun-yu DONG

Frontiers of Information Technology & Electronic Engineering 2018, Volume 19, Issue 11,   Pages 1385-1396 doi: 10.1631/FITEE.1700262

Abstract:

Spectral clustering is one of the most popular and important clustering methods in pattern recognitionTo address this problem, we propose a novel method called anchor-based spectral clustering (ASC) by employingBased on this mapping matrix, it is easy to approximate the spectral embedding of the original data.The proposed method, ASC, is compared to the classical spectral clustering and two state-of-the-art acceleratingExperimental results show that ASC is consistently faster than the classical spectral clustering with

Keywords： Clustering     Spectral clustering     Graph Laplacian     Anchors    

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CROP PROTECTION OPENS UP NEW ERA OF CONSERVATION AND UTILIZATION OF GREEN OPTIONS

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1,   Pages 1-3 doi: 10.15302/J-FASE-2021431

Abstract: Therefore, to solve the problem of crop pests and diseases, suitable green crop protection methods havemajor crop pests provides better pest management and acts as a fundamental part of an integrated plant protectiondocumenting the history of research and application, Chinese laws and regulations related to plant protection

Field management is a traditional conservation agriculture technique on plant protection such

Pesticides are widely used in the crop protection.

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Bioengineering protection mechanism of city rock slope and its laboratory test

Desong JIANG, Minghua ZHAO, Chong JIANG,

Frontiers of Structural and Civil Engineering 2009, Volume 3, Issue 4,   Pages 414-421 doi: 10.1007/s11709-009-0055-9

Abstract: Based on the features of rock slope bioengineering protection, the ecology protection mechanism of theFurthermore, the indoor model experiment of urban crag rock slope ecology protection was designed and

Keywords： indoor     engineering project     protection mechanism     different     runoff lagging    

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Title Author Date Type Operation

Salmonella-Delivered COBRA-HA1 Antigen Derived from H1N1 Hemagglutinin Sequences Elicits Broad-SpectrumProtection Against Influenza A Subtypes

Ram Prasad Aganja, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee

Journal Article

Applying the spectral stochastic finite element method in multiple-random field RC structures

Abbas YAZDANI

Journal Article

Fault feature extraction of planet gear in wind turbine gearbox based on spectral kurtosis and time wavelet

Yun KONG, Tianyang WANG, Zheng LI, Fulei CHU

Journal Article

Low-Cost Federated Broad Learning for Privacy-Preserved Knowledge Sharing in the RIS-Aided Internet of

Xiaoming Yuan,Jiahui Chen,Ning Zhang,Qiang Ye,Changle Li,Chunsheng Zhu,Xuemin Sherman Shen,

Journal Article

Implement and Innovate Environmental Protection Measures, Promote Green Protection of Cultural Relics

Fu-qing Liang,Yong-ping Sun

Journal Article

A Miniature Meta-Optical System for Reconfigurable Wide-Angle Imaging and Polarization-Spectral Detection

Fei Zhang,Minghao Liao,Mingbo Pu,Yinghui Guo,Lianwei Chen,Xiong Li,Qiong He,Tongtong Kang,Xiaoliang Ma,Yuan Ke,Xiangang Luo,

Journal Article

Nongray radiation from gas and soot mixtures in planar plates based on statistical narrow-band spectral

Huaqiang CHU, Qiang CHENG, Huaichun ZHOU, Fengshan LIU

Journal Article

Application of spectral technology in flame measurement

Jiaxun LIU, Xiaoshu CAI, Zenghao ZHU, Huinan YANG

Journal Article

Spectral characteristics of plant communities from salt marshes: A case study from Chongming Dongtan,

ZHANG Liquan, GAO Zhanguo, Armitage Richard, Kent Martin

Journal Article

Spectral element modeling based structure piezoelectric impedance computation and damage identification

Zhigang GUO, Zhi SUN

Journal Article

Rapid and long-effective removal of broad-spectrum pollutants from aqueous system by ZVI/oxidants

Sana Ullah, Xuejun Guo, Xiaoyan Luo, Xiangyuan Zhang, Siwen Leng, Na Ma, Palwasha Faiz

Journal Article

Technology of Measurement and Control by Welding Arc Spectral Information and Its Application

Li Junyue,Yang Yunqiang,Li Huan,Zhang Xiaonan,Yang Lijun

Journal Article

An anchor-based spectral clustering method

Qin ZHANG, Guo-qiang ZHONG, Jun-yu DONG

Journal Article

CROP PROTECTION OPENS UP NEW ERA OF CONSERVATION AND UTILIZATION OF GREEN OPTIONS

Journal Article

Bioengineering protection mechanism of city rock slope and its laboratory test

Desong JIANG, Minghua ZHAO, Chong JIANG,

Journal Article